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  • 2024-07-25

    IF 13.3! Promoting nerve regeneration: peripheral nerve injury (PNI) chip empowers high-speed biomaterials and drug screening
    Peripheral nerve injury (PNI) is a major challenge in regenerative medicine, often leading to long-term functional impairment. In this study, we introduced the Peripheral Nerve Injury Chip (PNI Chip), a cutting-edge platform designed specifically for high-speed screening of biomaterials and drugs to
  • 2024-07-25

    IF 29.4! Metal Drug Coordination Nanoparticles And Hydrogels for Enhanced Delivery
    药物递送是纳米医学的关键组成部分,传统的递送依赖于药物分子对纳米材料的吸附或封装。许多运载工具含有金属离子,例如金属有机框架、金属氧化物、过渡金属二硫属化物、MXene 和贵金属纳米颗粒。这些材料金属含量高,存在潜在的长期毒性问题,导致临床批准困难。在这篇综述中,总结了使用药物分子作为金属配位形成各种纳米材料和软材料的配体的最新进展。在这些情况下,药物与金属的比率远高于传统的基于吸附的策略。药物分子分为小分子药物、核酸和蛋白质。形成的杂化材料主要包括纳米颗粒和水凝胶,可以在其上接枝靶向配体以提高功效并进一步降低毒性。综述了这些材料在解决癌症、病毒感染、细菌感染、炎症性肠病和骨疾病方面的应用。最
  • 2024-07-24

    Preparation of rod-shaped boronic ester affinity imprinted covalent organic frameworks (COFs) interconnected with polyHIPE for selective high-throughput separation of flavonoids
    Functionalized covalent organic frameworks (COFs) have attracted great attention in the field of separation. However, the application of COFs adsorbents under complex flavonoid separation conditions still faces many difficulties.
  • 2024-07-24

    Ultra small tetravalent MOF nanocrystals with high defects
    The size and defects of crystalline inorganic materials are crucial in many applications, especially in catalysis, as they often lead to enhanced/emerging performance. So far, the application of modulation chemistry strategies has not been able to provide high-quality functional metal organic framew
  • 2024-07-24

    Design of a mixed matrix MOF membrane with asymmetric packing density and inherent MOF/polymer compatibility for enhancing molecular sieving
    Separating high value-added chemicals from organic solvents is important for many industries. Compared with traditional thermal processes, membrane based nanofiltration provides more energy-efficient separation.
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