English
The biological relevance of chirality has aroused strong interest in the regulation of pathology and biomedical activities. With a size scale that is commensurate with the biological environment, chiral inorganic nanomaterials can exhibit enzyme like properties, thereby determining the selectivity and directionality of biological activity. This chiral dependent function originates from chiral interactions or chiral light matter interactions at the chiral organic-inorganic interface, enabling high-precision molecular analysis and efficient biomedical therapy. This perspective provides an overview of the synthesis of chiral inorganic nanomaterials driven by biomolecules, the enantioselective interactions at organic-inorganic interfaces, and the biomedical applications of chiral dependent molecular sensing and therapy. The comparison of representative chiral inorganic nanostructures indicates that nanoscale control of chiral features is crucial for enhancing the ultimate chirality of inorganic nanomaterials. Therefore, a quantitative understanding of chiral organic-inorganic interfaces and a more systematic regulation of their relationships, such as the systematic integration of sequence programmable biomolecules (such as DNA or proteins), is considered a potential direction for the research of biomedical functional chiral inorganic nanomaterials.
