The demand for high food safety standards, prevention of corruption, and minimizing food waste has prompted extensive research on smart food packaging. In this field, two-dimensional (2D) nanomaterials have received considerable attention due to their extremely thin layered structure and diverse physical, chemical, electrical, optical, and thermal properties. These properties make two-dimensional nanomaterials highly suitable for enhancing the sensing capabilities of intelligent packaging systems. This review delves into the cutting-edge research on the utilization of two-dimensional nanomaterials in intelligent packaging applications. It conducted a comprehensive investigation into the concept of smart food packaging and explored various 2D materials, including graphene based materials, MXene, and silicate clay, and studied their potential in smart packaging systems. In addition, the comment also explains the structure, characteristics, and utilization of two-dimensional materials in various biosensing systems, including gas, humidity, pH, and bacterial sensors, indicators, or wireless tags. In addition, it also studied the effects of two-dimensional materials on the mechanical, optical, thermal, barrier, and biologically active properties of smart packaging, while also exploring their respective advantages and limitations. By combining these fundamental elements, this study has made a unique and thorough contribution to the field of food packaging, laying the foundation for the future development of sustainable and high-performance packaging materials.