English
Since the discovery of Fe3O4 nanoparticles with enzyme like activity in 2007, significant progress has been made in the study of nanoenzymes. With the deepening of research on various nanoenzymes and the rapid development of related nanotechnology, nanoenzymes have become a promising alternative to natural enzymes. Among nanoenzymes, there is a type of metal based single atom nanoenzyme that has rapidly developed due to its low cost, convenient preparation, long storage time, low immunogenicity, and especially high efficiency. More importantly, single atom nanoenzymes have the ability to clear reactive oxygen species through various mechanisms, which is beneficial for tissue repair processes. Here, this article systematically focuses on the types of metal single atom nanoenzymes, their catalytic mechanisms, and their latest applications in tissue repair. Identified the existing challenges and proposed the future research prospects of nanoenzymes composed of metal nanomaterials. We hope that this review can elucidate the potential of single atom nanoenzymes in tissue repair and encourage their subsequent clinical translation.
