English
Given the increased risk of infection, high treatment costs, and emergence of drug-resistant strains, catheter-related urinary tract infections CAUTI poses significant clinical challenges on a global scale.
Despite extensive clinical efforts, such as anti the development of bacterial conduits and prevention methods, but due to the complexity of the microenvironment, the ongoing demand for antibacterial agents, and the limitations of anti biofilm strategies the necessity and concurrent inflammatory reactions to address CAUTI remain complex.
Here, a method for prevention has been introduced CAUTI's innovative solution involves ultra-low load gold/iron co doped silver peroxide nanoenzyme enhanced hydrogel coating.
Silicon the adhesive catheter is modified through a simple and cost-effective chemical process, endowing it with multi enzyme like activity, including peroxidase and with catalase like functions, these functions exhibit antibacterial, anti biofilm, and anti-inflammatory properties targeting the unique urinary tract microenvironment sex.
In addition, the hydrogel coating enhances the hydrophilicity of the catheter, thereby improving patient comfort.
The experiment confirmed the change the efficacy of good ducts in inhibiting bacterial colonization, reducing biofilm formation, enhancing oxygen supply, and regulating immune responses.
This item the study not only proposed alternative strategies for preventing and treating CAUTI, but also provided a promising therapy through utilizing multi enzyme nanoenzymes to meet various therapeutic needs.
