English
Artificial skin involves multidisciplinary efforts, including materials science, biology, medicine, and tissue engineering. Recent research aims to create skin that is multifunctional, intelligent, and capable of regenerating tissues. In this work, we proposed a specialized 3D printing ink composed of polyurethane and bioactive glass (PU-BG), and prepared a dual functional skin patch using microfluidic 3D bioprinting (MRBP) technology.
MRBP endows skin patches with highly controllable microstructure and excellent strength. In addition, asymmetric three-layer structures were further constructed through hydrogen bonding and gradient structures from hydrophilic to superhydrophilic
The dual transport mechanism promotes cell adhesion and growth.
More importantly, by combining the characteristics of biomedical skin with electronic skin (e-skin), we have achieved a dual functional skin patch for biomedical and electronic applications. In vivo experiments have shown that this skin patch can enhance hemostasis, resist bacterial growth, stimulate vascular regeneration, and accelerate the healing process. At the same time, it also mimics the sensory function of natural skin, achieving signal detection with a sensitivity of up to 5.87kPa, and has cyclic stability (over 500 cycles), a wide detection range of 0-150kPa, and high pressure resolution of 0.1% under 100 kPa pressure. This work provides a universal and effective method for creating dual functional skin patches, and offers new insights for wound healing and tissue repair, which is of great significance for clinical applications.
