Ultra thin two-dimensional nanomaterials (U2DNM) are a unique material with a thickness close to atoms and infinite lateral dimensions. This type of nanomaterial typically has strong intra layer covalent bonds and weak interlayer van der Waals bonds. Two dimensional electronic confinement provides unique electronic, physical, and chemical properties that do not exist in the corresponding bulk materials, making two-dimensional properties crucial. Importantly, adjustable surface chemistry provides a wide range of promising applications for separation science membranes, solid electrolytes for battery applications, energy storage, tissue engineering, optical materials, magnetic materials, sensing, catalytic applications, and other materials science applications. Two dimensional coordination nanosheets (2DCN) are the latest member of the U2DNM family, characterized by metal ions and ligands with multiple donor atoms. The numerous possible combinations between metal ions and multidentate ligands with various donor atoms provide opportunities for fine-tuning the physical and chemical properties of 2DCN, leading to many exciting applications. Lanthanide based 2D coordination nanosheets (Ln-2DCN) are becoming increasingly popular in 2DCN due to their potential applications in various fields such as optoelectronics, sensors, and biomedical analysis. In this review, we summarize the latest advances in 2D coordination nanosheets based on lanthanide elements, emphasizing their practical applications and relevance in today's scientific field. We have provided a detailed description of the synthesis techniques and appropriate characterization methods. In addition, we discussed the applications of Ln-2DCN in upconversion luminescent materials, magnetic materials, biomedical analysis, and sensing platforms. After reviewing the current progress, we discussed the difficulties and opportunities in this inspiring field.