MOF and MOF based composite materials as next-generation wound healing and dressing materials

In recent years, there has been increasing interest in developing innovative materials and treatment strategies to improve wound healing outcomes, particularly for chronic wounds and antimicrobial resistance. Metal organic frameworks (MOFs) represent a promising class of next-generation wound healing and dressing materials. Their high surface area, pore structure, stimulus responsiveness, antibacterial properties, biocompatibility, and potential for combination therapy make them suitable for addressing complex wound care challenges. MOF based composite materials can promote cell proliferation, angiogenesis, and matrix synthesis, serving as carriers of bioactive molecules and promoting tissue regeneration. They also have stimulus responsiveness and can be used for photothermal therapy for skin cancer and infections. This article provides a critical analysis of the current research status of MOFs and MOF based composite materials for wound healing and dressings, offering valuable insights into the potential applications, challenges, and future directions in this field. This literature review focuses on the multifunctionality of MOFs in wound disease treatment and healing from different perspectives, and discusses the latest developments in this field. In this context, potential readers will discover how MOFs contribute to this field to produce more effective, functional, and innovative dressings, as well as how they generate the next generation of biomaterials for skin treatment and regeneration.