Biodegradable biomedical elastomers (DBE) have controllable biodegradability, excellent biocompatibility, customized elasticity, and good network design and processing performance, and have become indispensable materials in tissue repair. This review critically examines the latest developments in bi

The selection of biomaterials is an important step in the development process of tissue engineering and regenerative medicine (TERM) applications. The selected biomaterial must have properties that allow several processes to mimic physiological replay, thereby rebuilding the homeostasis of tissue or

Nanodrugs that can aggregate in the tumor microenvironment (TME) have shown tremendous efficiency in improving therapeutic outcomes. The strategy of utilizing electrostatic interactions as a driving force to achieve intratumoral aggregation of nanomedicines has attracted widespread attention among v

The possibility of remotely manipulating intracellular pathways in single cells is one of the current goals of regenerative medicine, which requires new strategies to enhance tissue repair and reprogram stem cell activity. Due to the improved controlled synthesis that allows for convenient adjustmen

Peripheral nerve injury (PNI) is a major challenge in regenerative medicine, often leading to long-term functional impairment. In this study, we introduced the Peripheral Nerve Injury Chip (PNI Chip), a cutting-edge platform designed specifically for high-speed screening of biomaterials and drugs to

药物递送是纳米医学的关键组成部分，传统的递送依赖于药物分子对纳米材料的吸附或封装。许多运载工具含有金属离子，例如金属有机框架、金属氧化物、过渡金属二硫属化物、MXene 和贵金属纳米颗粒。这些材料金属含量高，存在潜在的长期毒性问题，导致临床批准困难。在这篇综述中，总结了使用药物分子作为金属配位形成各种纳米材料和软材料的配体的最新进展。在这些情况下，药物与金属的比率远高于传统的基于吸附的策略。药物分子分为小分子药物、核酸和蛋白质。形成的杂化材料主要包括纳米颗粒和水凝胶，可以在其上接枝靶向配体以提高功效并进一步降低毒性。综述了这些材料在解决癌症、病毒感染、细菌感染、炎症性肠病和骨疾病方面的应用。最