PROTAC (ProteolysisTargeting Chimeras，蛋白降解靶向联合体)的概念**是在2001年由Crews等人提出，能够利用机体内天然存在的蛋白清理系统，降低蛋白水平而非抑制蛋白的功能。PROTAC技术经过20年的不断完善和发展，俨然成为目前新药研发领域最火热的技术之一，受到科研院所、药企和投资机构的青睐。PROTAC(Proteolysis TargetingChimeras)是一种治疗策略，旨在通过促使特定蛋白质在细胞内被泛素化和降解来调节蛋白质水平和功能。这种方法利用异双功能分子，包含一个与目标蛋白质结合的部分和一个与E3连接酶结合的部分。

Boosting flexible electronics with integration of two-dimensional materials

First author by Ariel J. Ben-SassonCorresponding authors: David Baker and Emmanuel DeriveryCommunication unit: University of Washington, MRC Molecular Biology Laboratory, CambridgeResearch Highlights:1. A new method for computational control of binary protein two-dimensional material assembly was de

First author by Ariel J. Ben-SassonCorresponding authors: David Baker and Emmanuel DeriveryCommunication unit: University of Washington, MRC Molecular Biology Laboratory, CambridgeResearch Highlights:1. A new method for computational control of binary protein two-dimensional material assembly was de

First author by Ariel J. Ben-SassonCorresponding authors: David Baker and Emmanuel DeriveryCommunication unit: University of Washington, MRC Molecular Biology Laboratory, CambridgeResearch Highlights:1. A new method for computational control of binary protein two-dimensional material assembly was de

First author by Ariel J. Ben-SassonCorresponding authors: David Baker and Emmanuel DeriveryCommunication unit: University of Washington, MRC Molecular Biology Laboratory, CambridgeResearch Highlights:1. A new method for computational control of binary protein two-dimensional material assembly was de