English
Nanocatalytic therapeutic agents with chemokinetic therapy (CDT), photothermal therapy (PTT) and photodynamic therapy (PDT) are emerging nanomaterials in the treatment of malignant tumors. However, the passive diffusion and transportation of nanomaterials lead to poor permeability in tumor lesions, which seriously affects the effect of synergistic therapy. In this paper, a double-source driven umbrella Au2Pt@PMO@ICG Janus nanomotors (APIJNS) were prepared by means of an interfacial energy-mediated anisotropic growth strategy for PTT-mediated CDT/PDT triple synergistic cancer therapy. The nanomotor can realize self-thermally driven drive under the excitation of near-infrared light, which can effectively enhance the active permeability and uptake of APIJNS in tumor tissues, so as to achieve efficient PTT/PDT/CDT synergistic therapeutic effect. In addition, the descending umbrella APIJNS showed high efficiency catalase (CAT) -like activity, which can catalyze overexpressed H2O2 in the tumor microenvironment (TME) to produce oxygen (O2), which not only alleviates the hypoxia in the tumor lesion, but also converts it into singlet oxygen (1O2) to activate photosensitizers ICG and achieve PDT. This work provides a new idea for improving tumor permeability and enhancing triple synergistic tumor therapy by using double-driven Janus nanomotors based on double noble metal nanomases.
